Cholestrol

Gene Mutation Can Cause High LDL

Scientists have discovered that there are two gene mutations which are linked to a specific location on chromosome 1 or more specifically on 1p13.3 chromosome which can result in high cholesterol levels (
high levels LDL cholesterol) in the body of some individuals.

Study was conducted on 11,000 individuals in Europe who were suffering from high cholesterol levels. Their blood samples were taken for analysis and studied thoroughly. The study concluded that there were two new genetic mutations in few individuals which has some association with the LDL cholesterol. These mutations were located on the chromosome 1 which has been considered to be linked to LDL cholesterol in the earlier studies.

This area of chromosome 1 plays a major in the development of heart disease, some earlier studies have already proved this so its association with LDL cholesterol has already been established as per the earlier studies. The earlier study has proved that the mutation in Apolipoprotein B and Apolipoprotein E along with the receptor of LDL cholesterol can result in higher levels of LDL in the body.

The recent study tries to establish the inheritance factor of cholesterol disorders like familial hypercholesterolemia, a condition where the levels of cholesterol remains high in spite of proper intake of diet and exercise.

No other discovery has proved this explanation more clearly as yet. It is for the same reason that intake of improper food and the sedentary lifestyle of the person is considered more responsible for the development of high cholesterol levels in the body.

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