Triglycerides Medication

Medications are to be taken if triglyceride levels are not lowered by dietary changes, other lifestyle changes and exercise. This article gives information about triglycerides medication.

Triglycerides Medication

HMG-CoA reductase inhibitors, known as statins are the most common drugs prescribed by the doctor. Lipitor, lescol, pravachol, zocor and mevacor are the common statin drugs. Generally, statins have no side effects. However, gastrointestinal upset, skin rash, headaches and sleep disturbance have been reported by some people.

Grapefruit juice should not be taken while using statin drugs. This juice contains a chemical which deactivates liver enzyme that breaks down statins. This leads to high levels of statins in the bloodstream, which causes statin toxicity symptoms like muscle aches, extreme tiredness and possibly heart malfunctioning. Also avoid alcohol when using statin drugs.

Another group of drugs that lower triglycerides are fibrates. They are usually less important for preventing heart disease, but they help to reduce VLDL and LDL cholesterol. They also raise HDL blood cholesterol, although less than drugs in group 1.

Colifibrate is the first of these drugs to be widely used and the common cause noted was gallstones. It should be used only in people whose gallbladders have already been removed. Gemfibrozil also causes gallstones, although less possibly than colifibrate, and all the drugs in this group are suspect in this respect.

All of them can also cause an inflammatory disorder of muscle cells, particularly in people with kidney problems. Other side effects of fibrates include skin rash, liver problems, headaches, nausea and gastrointestinal discomfort.

A third group of drugs are nicotinic acid derivatives. Drugs in this group reduce VLDL and LDL (bad) blood cholesterol by preventing them being made in the body and also raise HDL (good) cholesterol level. Initially they cause an unpleasant sensation of blushing and prickly heat around the face and neck.

But, in most people this side effect wears off after 3-4 days and then does not return. Nicotinic acid can cause liver damage in over dosage. Although nicotinic acid is the first cholesterol lowering drug shown to reduce deaths from all causes in major drugs trial, it is less prescribed than any other agent. The only reason for this apart from flushing is that it ran out of patent protection.

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