Familial Combined Hyperlipidemia

A disorder of high blood triglycerides and high cholesterol which is passed through families is familial combined hyperlipidemia. This article gives information about familial combined hyperlipidemia.


Increased blood fats which cause early heart attacks is the most common cause. This is a genetic condition, which means this disorder is caused due to your genes problem. However, specific genes responsible for this condition are not yet identified. Alcoholism, hypothyroidism and diabetes worsen the condition.

Symptoms of Familial Combined Hyperlipidemia

  • People with this disorder develop high triglyceride or cholesterol levels during the teen years. The high levels remain throughout the life.
  • They experience an increased risk of coronary artery disease and heart attacks.
  • People with this condition have high rate of glucose intolerance and obesity.
  • Chest pain may also occur. However, physical symptoms may not appear.


Blood tests are to be done in order to check cholesterol and triglycerides level. Specific tests include:

  • Apolipoprotein B100 test
  • Serum LDL cholesterol
  • Serum HDL
  • Triglycerides


  • Treatment is carried out mainly to lower the risk of atherosclerosis.
  • Primary step involves change in diet. Before undergoing gene therapy, it is good to try diet change.
  • Diet changes include lowering intake of total fat to less than 30% of total calories consumed.
  • Intake of saturated fat can be lowered by reducing the amounts of chicken, beef, lamb and pork and also by eliminating palm and coconut oils.
  • Cholesterol intake can be reduced by eliminating organ meats and egg yolks.
  • Regular exercise and weight loss also helps to lower cholesterol levels.
  • The doctor may recommend medications if exercise, diet or weight loss efforts don’t lower your cholesterol levels.
  • Medicines that help to lower cholesterol include:


    Nicotinic acid


    Bile acid-sequestering resins

Possible Complications

  • Stroke
  • Heart attack
  • Early atherosclerotic heart disease

Consult your doctor if you have symptoms of heart attack or high triglycerides.

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