Cholesterol Absorption Inhibitors

Cholesterol absorption inhibitors are a class of compounds that prevent the absorption of cholesterol from small intestine into blood. These are effective in preventing the progression of atherosclerosis. The most important inhibitor is ezetimibe.

Role of Cholesterol Absorption Inhibitors- Ezetimibe


It is the first one to be proposed by the food and drug administration. Taking it prevents the absorption of dietary and billary cholesterol from small intestine. Taking ezetimibe along with statins is much effective for patients with hypercholesterolemia. It has profound effect in reducing ldl levels to about 15 to 20% and improving HDL levels to 2.5%. About 10mg per day is a effective dosage.

Treatment Using Ezetimibe


It is an inflammatory disorder. Atherosclerosis progresses by endothelial cell activation. This activation is caused due to the oxidation of lipoproteins. By taking ezetimibe one can prevent the progress of atherosclerosis and inhibit inflammatory mediator.


It is a rare disorder. This disorder is caused due to the increased absorption of plant sterols from the intestine. The patients suffering from this disease show symptoms of hemolysis, atherosclerosis and early coronary heart disease. When treated with ezetimibe,reduces the levels of sitosterol to about 21%. Ezetimibe when taken along with simvastatin is effective to reduce LDL(bad cholesterol) level to a large extent.

Cholesterol Absorption Inhibitors- Side Effects

  • Dizziness
  • Tiredness
  • Headache
  • Joint pain
  • Cold
  • Chest pain
  • Fever
  • Dark urine
  • Muscle pain
  • Loss of appetite

When Should One Avoid Using These Drugs?

  • If your suffering from liver disease stop using it.
  • Do not take drugs cholestyramine, colesevelam along with inhibitors.
  • These inhibitors can be taken with or without food.
  • Pregnant women should avoid taking it.
  • Regular health check up should be done while using these drugs to see if there are any side effects.

These inhibitors should be taken under controlled supervision of a doctor. If side effects occur it is better to consult a doctor.

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